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Postdoctoral Position – Fungal Gene Manipulation and Secondary Metabolites

May 8

Written by: SuperUser Account
5/8/2014 10:00 AM 

Postdoctoral Position – Fungal Gene Manipulation and Secondary Metabolites University of Hawaii Cancer Center, Honolulu, Hawaii Position description: A postdoctoral position focused on the activation of dormant genes for the production of secondary metabolites in fungi as anti-cancer compounds is available in the Cao lab. This project will use genetic approaches (e.g., modulation of global regulators, manipulation of regulation factors, and promoter exchange etc.) to investigate the gene regulation in model organisms (e.g., S. cerevisiae, Aspergillus, Fusarium, Penicillium spp. etc.) for fungal secondary metabolites. The methodologies will be applied to study endophytic and marine fungi collected in Hawaii; and mutant strains with specific differences in metabolite expression will be investigated for novel anti-cancer agents. Minimum requirements: Ph.D. from an accredited college or university in Molecular Biology with a specialization in mycology, fungal genetic, genomics, or related fields. Ability to activate the silent genes of endophytic and marine fungi using innovative genetic approaches for the production of novel natural products for their anti-cancer activity. Additional experience in sequencing and analysis of next-generation sequence data, bioinformatics and comparative genomics, HPLC, Mass Spectrometry, and NMR etc. Strong publication record; independence and creativity; very good written and oral communication skills. The initial appointment is for 1 year. Continuation of employment is dependent upon program/operational needs, availability of funds, satisfactory work performance, and compliance with applicable Federal/State laws. Start date is flexible. To apply: Interested applicants should contact Dr. Shugeng Cao (scao@hawaii.edu) and include a CV, a cover letter stating research interests and qualification, and contact information for three references. Screening of applicants will begin June 01, 2014 until a suitable candidate is found.


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